Lysophosphatidic acid (LPA) is a lipid mediator with a wide variety of biological actions, particularly as an inducer of cell proliferation, migration and survival. LPA binds to specific G‐protein‐coupled receptors and thereby activates multiple signal transduction pathways, including those initiated by the small GTPases Ras, Rho, and Rac. LPA signaling has been implicated in such diverse processes as wound healing, brain development, vascular remodeling and tumor progression. Knowledge of precisely how and where LPA is produced has long proved elusive. Excitingly, (...) it has recently been discovered that LPA is generated from precursors by ‘autotaxin’, a once enigmatic exo‐phosphodiesterase implicated in tumor cell motility. Exogenous phospholipases D can also produce LPA, which may contribute to their toxicity. Here we review recent progress in our understanding of LPA bioactivity, signaling and synthesis. BioEssays 26:870–881, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

The Dutch law states that a physician may perform euthanasia according to a written advance euthanasia directive when a patient is incompetent as long as all legal criteria of due care are met. This may also hold for patients with advanced dementia. We investigated the differing opinions of physicians and members of the general public on the acceptability of euthanasia in patients with advanced dementia.

In the present article we argue that emotional interactions are not appropriately captured in present emotion research and theorizing. Emotional stimuli or antecedents are dynamic and change over time because they often interact and have a specific relationship with the subject. Earlier emotional interactions may, for example, intensify later emotional reactions to a specific person, or our anger reactions towards powerful or powerless others may differ considerably. Thus, we suggest that such social factors not only affect the intensity, but also (...) the nature of emotional experiences and expressions, and specifically the nature of the social movement (e.g., moving towards, away, or against). We discuss different processes that are implicated in the relation between the social environment and our emotions, describe how emotional expressions shape social behavior, and provide suggestions for incorporating the social dimension of emotion in future research. (shrink)

The Cambridge Companion to Spinoza. Don Garrett (ed.). Cambridge University Press, 1996, pp. xiii, 465. ISBN 0-521-39235-7 (hb); ISBN 0-521-39865-7 (pb). 40.00 (hb) 12.95 (pb). Spinoza: The Enduring Questions. Graeme Hunter (ed.). University of Toronto Press, 1994, pp. xviii, 182. ISBN 0-8020-2876-4. 45.00. The Spinozistic Heresy: The Debate on the 'Tractatus Theologico-Politicus'. 1670-77. Paolo Cristofolini (ed.). APA-Holland University Press: Amsterdam and Maarssen, 1995, pp. viii, 260. ISBN 90-302-1502-X. Disguised and Overt Spinozism around 1700. Wiep van Bunge and Wim Klever (eds.). (...) Brill, Leiden, 1996, pp. ix, 378. ISBN 90-04-10307-4. Part of Nature: Self-Knowledge in Spinoza's 'Ethics', by Genevieve Lloyd. Cornell University Press, Ithaca and London, 1994, pp. 182. ISBN 0-8014-2999-4. 24.95. Spinoza and the 'Ethics', by Genevieve Lloyd. Routledge Philosophy Guidebooks, London, 1996, pp. x, 163. ISBN 0-415-10782-2 (pb). 6.99. Spinoza: The Way to Wisdom, by Herman de Dijn. Purdue University Press, West Lafayette, Indiana, 1996, pp. xii, 291. ISBN 1-55753-081-5. (shrink)